Botulinum toxin A (BoNT/A) was surfaced in this screen as a high-ranking treatment for depression. As Many as 12 clinical studies were identified, with 7 randomized, placebo-controlled trials.
Lenalidomide-Dexamethasone as an Effective and Well-Tolerated Treatment Option for Refractory Rosai-Dorfman-Destombes Disease: A Clinical and Pharmacophenomic Study
Rosai-Dorfman-Destombes (RDD) disease is a rare histiocytic neoplasm that commonly presents with skin and subcutaneous masses, lymphadenopathy, and bone lesions. Management is guided by disease extent, symptom burden, presence of targetable mutations, and treatment response
Quantify unmet medical need across the disease landscape – A large language model-based methodology
Despite the ultimate goal of medical researchers and funders being to maximize patient benefit, there is no systematic process for quantifying unmet medical need across diseases. While a relative unmet medical need scoring system would be valuable for prioritization of medical research, systematically performing this effort across all 22,701 human diseases is technically challenging, time-consuming, […]
Barriers and Solutions Across Drug Repurposing Archetypes
Millions of patients worldwide live with conditions that have no approved treatments or face barriers to accessing existing therapies. Every Cure, a nonprofit on a mission to save and improve lives by repurposing drugs, categorizes drug repurposing opportunities into four archetypes based on their stage of evidence and adoption…
Computational Pharmacophenomics
Pioneering a new field of computational pharmacophenomics to unlock the life-saving potential of existing medicines
