In 2010, Every Cure’s cofounder Dr. David Fajgenbaum was a third-year medical student when he became critically ill with Castleman disease (CD). He spent months hospitalized in critical condition and nearly died five times. David was told there were no more options for his disease and waiting for a new treatment – requiring billions of research dollars and 10-15 years – was not a possibility. Repurposing an existing drug was his only hope. David launched an initiative to find treatments to save his life and the lives of others with CD. He and his team discovered an overactive pathway in his blood and tested a 25-year-old drug called sirolimus that was approved as an immunosuppressant after kidney transplants but had never been used for CD, to block that pathway. As a result of this repurposed drug, David has been in remission for more than 11 years.
On a mission to unlock the full potential of every drug
In the last 10 years, Dr. Fajgenbaum’s team has advanced 14 repurposed drugs for multiple diseases and they are scaling this work through Every Cure. Every Cure was founded to ensure that patients don’t suffer while potential treatments hide in plain sight. For the first time, AI can leapfrog over repurposing barriers, unlocking cures at a fraction of the cost and time. Our AI approach enables rapid and systematic analysis of the world’s biomedical knowledge. While traditional research would take years to investigate all diseases, our approach looks across all 18K diseases and 4K drugs, quantifying the strength of 75M drug-disease matches within days. Our team assesses the highest potential matches, generates evidence about effectiveness through research and validation and disseminates successes in partnership with patient organizations, democratizing medical insights and reducing health inequities worldwide.
Together, with partners in medicine, pharma, tech, and philanthropy, we are building out a comprehensive, open-source database of drug-repurposing opportunities.
Having established deep credibility across the drug repurposing landscape, we strive to be the vital connector within the ecosystem, uniting partners and fostering collaboration to unlock the full potential of existing medicines.
We are deeply passionate about uncovering repurposed drugs for patients who are suffering while there is a drug sitting at their neighborhood pharmacy, and want to scale drug repurposing to help each and every patient who may benefit by using an already existing drug.
Learn more about how you can help pursue this mission.