Since the advent of modern medicine, the scientific community has developed more than 3,000 drugs for thousands of diseases. Despite significant progress, there are more than 6,500 rare diseases without a single approved treatment.

David Fajgenbaum discovered a repurposed drug to save his own life and is now on a mission with Every Cure Co-Founders Grant Mitchell and Tracey Sikora to repurpose drugs for millions more.

He’s alive thanks to a repurposed drug. Now his dream is to find cures for millions of people from among drugs we already have.

While rare diseases are defined as conditions affecting fewer than 200,000 individuals, the shortage of rare disease treatments in the United States is a significant and pressing issue that affects countless individuals and their families who are grappling with often life-threatening medical conditions

On September 23rd, Every Cure Co-Founder David Fajgenbaum addressed Chan Zuckerberg Initiative’s Rare as One Network at the Science in Society Annual Meeting about the learnings and opportunities from his work to found and lead Every Cure, a nonprofit drug development organization focused on advancing repurposed treatments. 

Every Cure Co-founder Dr. David Fajgenbaum addressed the audience at the Clinton Global Initiative 2023 Meeting by giving Every Cure’s Commitment to Action to unlock the full potential of existing medicines to treat every disease and every patient they possibly can.

Partnerships with the Chan Zuckerberg Initiative, Flagship Pioneering, Lyda Hill Philanthropies, and Elevate Prize Foundation Will Accelerate the Discovery of Cures Hidden on Pharmacy Shelves

Board of Directors will lead the nonprofit organization on its mission of unlocking hidden cures.

Research driven by patients with rare diseases is producing faster discoveries and treatments—and challenging long-held assumptions about knowledge production.

Imagine feeling like you’ve contracted the flu, only to fall into a coma three days later. This was Gary’s reality, an experience he describes as having “fatigue on a different level.” This wasn’t any ordinary illness; this was Castleman Disease. Through the heartbreaking and hope-filled chapters of Gary’s journey, the undeniable power of drug repurposing […]

Have you read the story of David Fajgenbaum, a physician who was diagnosed with the rare disease called Castleman disease?

An Angiosarcoma patient facing a grave prognosis found a lifeline in a repurposed PD-1 inhibitor, a treatment hidden in the medical literature for three years. Every Cure and its partners are building on this breakthrough, deploying innovative AI algorithms that evaluate the potential of every drug for every disease. The efforts have already begun to […]

In a recent address to the Rare Disease Congressional Caucus, David Fajgenbaum, the co-founder of Every Cure, unveiled the organization’s mission to repurposing FDA-approved drugs for diseases that currently have no cure. By leveraging the vast pharmaceutical world’s existing knowledge, Every Cure aims to revolutionize treatment paradigms for thousands who have been told, “We’ve tried […]

A patient’s life was saved after researchers at the University of Pennsylvania, Castleman Disease Collaborative Network, Medidata, and Every Cure, used artificial intelligence to use an existing drug to treat idiopathic multicentric Castleman disease (iMCD).

Of course, AI was on everyone’s minds at the conference. However, it was the proof points and examples shared by leaders from multiple organizations that signaled the dramatic surge in impact.

The adoption of AI is accelerating across the entire CRO space as we start to explore the benefits of the tech. Whether being utilised for CRO expansion, streamlined clinical trials, better data analysis or another application we’ve yet to discover.

New York, New York – Every Cure, a nonprofit organization dedicated to unlocking the full potential of existing drugs for the treatment of various diseases, was highlighted at Clinton Foundation Gala. Co-founder Dr. David Fajgenbaum addressed attendees on the incredible progress Every Cure has made to date The event, held in New York, celebrated the […]

Every Cure has raised significant awareness over the last year and engaged with leaders across healthcare and government. In fact, Every Cure Co-Founders Grant Mitchell and David Fajgenbaum (pictured above) met with President Biden’s Chief of Staff, Jeff Zients, in the White House.

We are very excited to have Dr. David Fajgenbaum as our student-selected keynote speaker on this momentous occasion of our 50th commencement ceremony. His impressive and lofty goals and accomplishments will serve as a lasting inspiration to our students and anyone in attendance,” stated Dr. David Guzick, Chancellor of LSU Health Shreveport.

In September 2022, Fajgenbaum joined forces with longtime friend and fellow doctor Grant Mitchell, MD, and a group of experts at the University of North Carolina and beyond to leverage the power of machine learning to sift through the ocean of existing medical research to connect rare diseases to existing drugs. Their organization is called […]

Worldwide Clinical Trials (Worldwide), the industry’s leading global, full-service contract research organization (CRO), has partnered with Every Cure, a nonprofit organization that unlocks new, often undiscovered uses for existing approved drugs by leveraging data, artificial intelligence (AI), and efficient clinical trials.

David Fajgenbaum is an immunologist and co-founder of Every Cure, a nonprofit organization whose mission is to unlock the full potential of approved medicines to treat every disease possible. The organization, which he launched at the Clinton Global Initiative in 2022, employs AI to search through existing data to identify potential additional indications for approved […]

San Francisco, California – David Fajgenbaum, co-founder of Every Cure and physician-scientist at the University of Pennsylvania, announces First Life Saved with AI-Discovered Repurposed Medicine for Castleman Disease with Significant Potential Applications to Treat Other Illnesses

Fajgenbaum was having his last rites read to him, and his family braced for his death from Castleman disease, a rare inflammatory illness that impacts the lymph nodes and can severely damage other organs.

About a decade ago, David Fajgenbaum thought his life was over. He was a young, bright physician hoping to work in oncology in remembrance of his mother, who died of brain cancer a few years earlier. Fajgenbaum was having his last rites read to him, and his family braced for his death from Castleman disease, […]

David Fajgenbaum has become a “man on fire,” determined to repurpose as many generic drugs as possible for diseases without approved treatments. Fajgenbaum, whose efforts have been recognized by former President Bill Clinton, spoke with In Vivo about his own patient journey with a disease with no approved treatment and about the Every Cure Foundation, a non-profit […]

Two companies team up to combat rare diseases through drug repurposing, which was heavily informed by one doctor’s experience through unconventionally treating his Castleman disease and (ultimately) saving his own life. Two companies join forces to unlock the hidden potential in existing drugs to save lives suffering from rare diseases. In 2010, Dr. David Fajgenbaum, […]

David Fajgenbaum, MD, was a college football player at Georgetown University in 2004 when his mother passed away from cancer. The loss inspired the athlete to become a doctor himself: “I wanted to treat patients in memory of my mom,” he says. But three years into medical school, the then-25-year-old’s health took a turn for […]

As many as 7,000 rare diseases affect 300 million people globally. The vast majority are not well understood, and less than 5 percent have approved treatments. Yet, patients are meeting these challenges head-on. Dr. Fajgenbaum was diagnosed with Castleman disease, a rare disorder that involves an overgrowth of cells in your body’s lymph nodes. The most […]

Dr. David Fajgenbaum is not afraid to think outside the box and that is what saved his life. While in medical school, the former college athlete suddenly became critically ill. Doctors told him he was suffering from a rare disorder called Castleman disease; his immune system was attacking his vital organs, potentially leading to life-threatening […]

It was the night before April Fools’ Day, 2021, when Dr. David Fajgenbaum received the text: President Clinton read your book and would like to talk. Despite the outpouring of praise for his bestselling memoir, Chasing My Cure – an astounding chronicle of Fajgenbaum’s five near-death experiences from Castleman disease and his successful search to […]

The Philadelphia physician has the distinction of researching – and solving – his own rare disease. Learn more about this prolific advocate for rare disease patients. Maybe it’s the brush with death that David Fajgenbaum had at a young age that gave him an extra charge of energy, a powerful desire to get things done.

For biotechs, the JP Morgan Healthcare Conference is about dealmaking in many forms—securing financing, establishing development partnerships, courting mergers and acquisitions—by wooing would-be partners and investors with a value proposition. Everyone’s in schmooze-and-pitch mode, and everyone’s seeking to capitalize on the momentum the show generates in the news cycle.

Medable has announced a collaboration with non-profit Every Cure for conducting global, remote clinical trials for drug repurposing candidates. Every Cure was officially launched, in collaboration with the Clinton Global Initiative, in September to scale up a new ‘drug repurposing’ research approach for identifying rare disease treatments.

Medable Inc., the industry-leading technology platform for patient-centered clinical trials, today announced a partnership with non-profit Every Cure, which officially launched in September in partnership with the Clinton Global Initiative to scale up an innovative “drug repurposing” research approach to identify treatments for rare diseases.  

President Biden found a copy of the book “Chasing My Cure” on his desk, a gift from none other than former President Clinton.

This week, an exciting interview from our archive airs on Oct. 8, 2022. A healthy young medical student, David Fajgenbaum, had been a student athlete in college and maintained his extraordinary level of fitness through much of medical school. Because of his enthusiasm and athleticism, his friends called him The Beast. When he suddenly found […]

A new nonprofit backed by the Clinton Global Initiative aims to identify generic drugs that could help people with rare diseases. Every Cure is based on the concept that every drug on the market has multiple effects on the body, not just the one or two that first earned its approval.

Approximately 75% of human diseases don’t have a single FDA-approved treatment. That fact nearly cost Dr. David Fajgenbaum his life, and at #CGI2022, he announced a Commitment to Action that aims to change it:

Former President Bill Clinton is calling on governments, businesses, philanthropies and other prominent institutions to draw together and help a world that is “on fire” as he reconvenes the Clinton Global Initiative, the meeting of international leaders, for the first time since 2016.

A new nonprofit backed by the Clinton Global Initiative aims to identify generic drugs that could help people with rare diseases. Every Cure is based on the concept that every drug on the market has multiple effects on the body, not just the one or two that first earned its approval.

Every drug on the market has multiple effects on the body, not just the one or two that won it approval. A new nonprofit aims to exploit those other effects to help patients with rare diseases.